Pair Name	Curcumin, Quinacrine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	ABCG2	hsa9429
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	NOS3	hsa4846
In Vitro Model	SP	Healthy	Homo sapiens (Human)	CVCL_C4PJ
In Vivo Model	The tumor tissue was cut into small pieces. Then, a deep incision was made in the anterior region of Balb/C mice using a scissor and then 5-6 chopped tumor tissue pieces were implanted in the anterior peritoneal wall within 3 h of collecting tumor tissues from the patient.
Result	Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A